{"id":19279,"date":"2024-03-01T08:29:51","date_gmt":"2024-03-01T15:29:51","guid":{"rendered":"https:\/\/emrabc.ca\/?p=19279"},"modified":"2024-03-06T11:05:48","modified_gmt":"2024-03-06T18:05:48","slug":"wireless-control-of-cellular-function-by-activation-of-a-novel-protein-responsive-to-electromagnetic-fields","status":"publish","type":"post","link":"https:\/\/emrabc.ca\/?p=19279","title":{"rendered":"Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields"},"content":{"rendered":"<div class=\"rendering rendering_researchoutput rendering_researchoutput_associatespersonsclassifiedportal rendering_contributiontojournal rendering_associatespersonsclassifiedportal rendering_contributiontojournal_associatespersonsclassifiedportal\">\n<p class=\"relations persons\">Vijai Krishnan, Sarah A. Park, Samuel S. Shin, Lina Alon, <a class=\"link person\" href=\"https:\/\/pure.johnshopkins.edu\/en\/persons\/cay-tressler\" rel=\"Person\">Caitlin M. Tressler<\/a>, William Stokes, Jineta Banerjee, Mary E. Sorrell, Yuemin Tian, <a class=\"link person\" href=\"https:\/\/pure.johnshopkins.edu\/en\/persons\/gene-fridman\" rel=\"Person\">Gene Y. Fridman<\/a>, <a class=\"link person\" href=\"https:\/\/pure.johnshopkins.edu\/en\/persons\/pablo-celnik\" rel=\"Person\">Pablo Celnik<\/a>, Jonathan Pevsner, <a class=\"link person\" href=\"https:\/\/pure.johnshopkins.edu\/en\/persons\/bill-guggino\" rel=\"Person\">William B. Guggino<\/a>, Assaf A. Gilad, Galit Pelled<\/p>\n<\/div>\n<div class=\"rendering rendering_researchoutput rendering_researchoutput_associatesorganisationsportal rendering_contributiontojournal rendering_associatesorganisationsportal rendering_contributiontojournal_associatesorganisationsportal\">\n<ul class=\"relations organisations\">\n<li class=\"division\"><a class=\"link\" href=\"https:\/\/pure.johnshopkins.edu\/en\/organisations\/school-of-medicine-3\" rel=\"Organisation\">School of Medicine<\/a><\/li>\n<li class=\"division\"><a class=\"link\" href=\"https:\/\/pure.johnshopkins.edu\/en\/organisations\/kennedy-krieger-institute-3\" rel=\"Organisation\">Kennedy Krieger Institute<\/a><\/li>\n<\/ul>\n<\/div>\n<div class=\"rendering rendering_researchoutput rendering_researchoutput_publicationcontenttyperendererportalng rendering_contributiontojournal rendering_publicationcontenttyperendererportalng rendering_contributiontojournal_publicationcontenttyperendererportalng\">\n<p class=\"type\"><span class=\"type_family\">Research output<span class=\"type_family_sep\">: <\/span><\/span><span class=\"type_classification_parent\">Contribution to journal<span class=\"type_parent_sep\"> \u203a <\/span><\/span><span class=\"type_classification\">Article<\/span><span class=\"type_classification\"><span class=\"type_parent_sep\"> \u203a <\/span>peer-review<\/span><\/p>\n<h2 class=\"subheader\">Abstract<\/h2>\n<div class=\"rendering rendering_researchoutput rendering_researchoutput_abstractportal rendering_contributiontojournal rendering_abstractportal rendering_contributiontojournal_abstractportal\">\n<div class=\"textblock\">\n<p>The Kryptopterus bicirrhis (glass catfish) is known to respond to electromagnetic fields (EMF). Here we tested its avoidance behavior in response to static and alternating magnetic fields stimulation. Using expression cloning we identified an <strong>electromagnetic perceptive gene (EPG)<\/strong> from the K. bicirrhis encoding a protein that responds to EMF. This EPG gene was cloned and expressed in mammalian cells, neuronal cultures and in rat&#8217;s brain. Immunohistochemistry showed that the expression of EPG is confined to the mammalian cell membrane. Calcium imaging in mammalian cells and cultured neurons expressing EPG demonstrated that remote activation by EMF significantly increases intracellular calcium concentrations, indicative of cellular excitability. Moreover, wireless magnetic activation of EPG in rat motor cortex induced motor evoked responses of the contralateral forelimb in vivo. Here we report on the<strong> development of a new technology for remote, non-invasive modulation of cell function.<\/strong><\/p>\n<\/div>\n<\/div>\n<div class=\"rendering rendering_researchoutput rendering_researchoutput_detailsportal rendering_contributiontojournal rendering_detailsportal rendering_contributiontojournal_detailsportal\">\n<div class=\"article\">\n<table class=\"properties\">\n<tbody>\n<tr class=\"language\">\n<th scope=\"row\">Original language<\/th>\n<td>English (US)<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Article number<\/th>\n<td>8764<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Journal<\/th>\n<td><a class=\"link\" tabindex=\"-1\" href=\"https:\/\/pure.johnshopkins.edu\/en\/publications\/wireless-control-of-cellular-function-by-activation-of-a-novel-pr#\" rel=\"Journal\">Scientific reports<\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Volume<\/th>\n<td>8<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Issue number<\/th>\n<td>1<\/td>\n<\/tr>\n<tr class=\"status\">\n<th scope=\"row\">State<\/th>\n<td><span class=\"prefix\">Published &#8211; <\/span><span class=\"date\">Dec 1 2018<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>source : <a href=\"https:\/\/pure.johnshopkins.edu\/en\/publications\/wireless-control-of-cellular-function-by-activation-of-a-novel-pr\">https:\/\/pure.johnshopkins.edu\/en\/publications\/wireless-control-of-cellular-function-by-activation-of-a-novel-pr<\/a><\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19277\" src=\"https:\/\/emrabc.ca\/wp-content\/uploads\/2024\/03\/novelprotein.jpg\" alt=\"\" width=\"860\" height=\"966\" srcset=\"https:\/\/emrabc.ca\/wp-content\/uploads\/2024\/03\/novelprotein.jpg 860w, https:\/\/emrabc.ca\/wp-content\/uploads\/2024\/03\/novelprotein-267x300.jpg 267w, https:\/\/emrabc.ca\/wp-content\/uploads\/2024\/03\/novelprotein-768x863.jpg 768w\" sizes=\"auto, (max-width: 860px) 100vw, 860px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Kryptopterus bicirrhis (glass catfish) is known to respond to electromagnetic fields (EMF). Here we tested its avoidance behavior in response to static and alternating magnetic fields stimulation. Using expression cloning we identified an electromagnetic perceptive gene (EPG) from the K. bicirrhis encoding a protein that responds to EMF. This EPG gene was cloned and expressed in mammalian cells, neuronal cultures and in rat\u2019s brain.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,903,811,896],"tags":[],"class_list":["post-19279","post","type-post","status-publish","format-standard","hentry","category-ehs","category-kryptopterus-bicirrhis-glass-catfish","category-nano","category-smart-health"],"_links":{"self":[{"href":"https:\/\/emrabc.ca\/index.php?rest_route=\/wp\/v2\/posts\/19279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/emrabc.ca\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/emrabc.ca\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/emrabc.ca\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/emrabc.ca\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19279"}],"version-history":[{"count":2,"href":"https:\/\/emrabc.ca\/index.php?rest_route=\/wp\/v2\/posts\/19279\/revisions"}],"predecessor-version":[{"id":19285,"href":"https:\/\/emrabc.ca\/index.php?rest_route=\/wp\/v2\/posts\/19279\/revisions\/19285"}],"wp:attachment":[{"href":"https:\/\/emrabc.ca\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/emrabc.ca\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/emrabc.ca\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}